How does pre-existing immunity interact with other factors to impact influenza vaccine responses?

A panel plot showing some of our findings–in the homologous case, we saw what we expected, but there are differences in vaccine dose and age that were not included in previous predictions. Additionally, the heterologous case needs further exploration.

I gave a two-minute lightning talk at the CIVR-HRP (Center for Influenza) annual meeting in Fall 2021. CIVR-HRP is an NIH-funded CIVIC (Collaborative Influenza Vaccine Innovation Centers) site at the University of Georgia, Athens, GA, USA, but the meeting was held virtually due to COVID-19. There were no virtual poster presentations, so I gave a lightning talk instead.

The slides can be found here. They are also embedded below. In short, we used vaccine cohort data, and found that the data were consistent with some predictions of prior mechanistic models, but not all.